Endocrine Abstracts

Introduction: The signaling involved in ligand-stimulated spermatozoa is not yet clarified. Moreover, the main question in sperm biology is the identification of the sperm ligands. Analysis of the role of MAPK in mammalian sperm physiology is a prerequisite for assigning a role for MAPK in mammalian sperm functions. The unique opportunity to study ERK1/2 in human spermatozoa, which are differentiated cells lacking active transcriptional machinery, will enable to correlate it t...

Introduction: We have recently described a preformed signalosome associated with the GnRH receptor (GnRHR), which undergoes dynamic rearrangement upon stimulation with GnRH. This signaling complex included c-Src, focal adhesion kinase (FAK), paxillin, vinculin, tubulin, caveolin-1, protein kinase C (PKC) δ, PKCε, PKCα, Ras, kinase suppressor of Ras-1 (KSR), MAPK kinase (MEK) 1/2, ERK1/2 and the GnRHR. To sort out the role of the signalosomes associated with the ...

Prostaglandin F2a (PGF) receptor (FP) expression is up-regulated in neoplastic epithelial and perivascular cells in endometrial adenocarcinomas, indicating potential regulation of vascular function by PGF via the FP receptor. This study investigated the potential role of PGF-FP receptor signalling in modulating vascular function in endometrial adenocarcinomas.Endometrial biopsies were obtained in accordance with Ethics Committee guidance with ...

Pituitary gonadotropes (LH and FSH producing cells) are simultaneously exposed to numerous stimuli, which exert multiple signalling pathways that cross-talk with the GnRH receptor (GnRHR). A model downstream effector system is the prostanoid family. Hence, prostanoid receptors and GnRHR might cross-talk and affect the biological responses of the gonadotropes. Here we report the expression of prostaglandin (PG) PGE2 receptors EP1, EP2, EP3 and EP4, the PGF2</sub...